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Mesothelioma Treatment Option:
Medical Procedures
The chance of recovery (mesothelioma prognosis) depends on the size of the cancer, where the cancer is, how
far the cancer has spread, how the cancer cells look under the microscope,
how the cancer responds to treatment, and the patient's age and general
health. Standard mesothelioma treatment may be considered because of its effectiveness in
patients in past studies, or participation in a clinical trial may be
considered.
There are a number of treatment options available to mesothelioma
patients. Extrapleural pneumonectomy in selected patient with very early
stage disease may improve recurrence-free survival, but its impact on
overall survival is unknown. Pleurectomy and Decortication can provide
palliative relief from symptomatic effusions, discomfort caused by tumor
burden, and pain caused by invasive tumors. The use of radiation therapy in
pleural mesothelioma has been shown to alleviate pain in the majority of
patients treated. Unfortunately, the duration of symptom control is
short-lived. Single agent and combined chemotherapy have reported higher
response rates in STAGE II patients, but the toxicity reported is also
higher, and there is no evidence that combination treatments result in
longer survival or longer control of the symptoms.
Standard Treatments
There are standard mesothelioma
treatments for all patients with malignant mesothelioma.
Three kinds of treatment are used:
1:
chemotherapy (using drugs to fight the cancer).
2:
surgery (taking out the cancer).
3:
radiation therapy (using high-dose x-rays or other high-energy rays
to kill cancer cells) chemotherapy (using drugs to fight the cancer).
Surgery is a common mesothelioma treatment of maligant-mesothelioma. The doctor may remove part of the lining of the
chest or abdomen and some of the tissue around it. Depending on how far the
cancer has spread, a lung also may be removed in an operation called a
pneumonectomy. Sometimes part of the diaphragm, the muscle below the lungs
that helps with breathing, is also removed.
Radiation therapy uses high-energy x-rays to kill cancer cells and
shrink tumors. Radiation may come from a machine outside the body (external
radiation therapy) or from putting materials that produce radiation
(radioisotopes) through thin plastic tubes in the area where the cancer
cells are found (internal radiation therapy). If fluid has collected in the
chest or abdomen, the doctor may drain the fluid out of the body by putting
a needle into the chest or abdomen and using gentle suction to remove the
fluid. If fluid is removed from the chest, this is called thoracentesis. If
fluid is removed from the abdomen, this is called paracentesis. The doctor
may also put drugs through a tube into the chest to prevent more fluid from
accumulating.
Chemotherapy uses drugs to kill cancer cells. Chemotherapy may be
taken by pill, or it may be put into the body by a needle in the vein or
muscle. Chemotherapy is called a systemic treatment because the drug enters
the bloodstream, travels through the body, and can kill cancer cells
throughout the body. In mesothelioma
treatment, chemotherapy may be put directly into the chest (intrapleural
chemotherapy).
Intraoperative photodynamic therapy is a new type of mesothelioma
treatment that uses special drugs and light to kill cancer cells during
surgery. A drug that makes cancer cells more sensitive to light is injected
into a vein several days before surgery. During surgery to remove as much of
the cancer as possible, a special light is used to shine on the pleura. This
treatment is being studied for early stages of mesothelioma in the chest.
Side Effects
Cancer and treatments all have side effects. It is hard to kill cancer cells
at the same time as keeping all healthy cells safe. Side effects of mesothelioma
treatment depend on the type of mesothelioma
treatment and the person's overall health when treatment starts.
Experimental Treatments
Not all patients are cured with standard therapy, and some standard mesothelioma
treatments may have more side effects than are desired. Clinical trials,
therefore, are designed to find better ways to treat cancer patients and are
based on the most up-to-date information. Clinical trials are ongoing in
many parts of the country for many patients with maligant-mesothelioma.
These new approaches often combine two or more traditional mesothelioma
treatments or consist of other promising innovations.
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